教授  博士研究生导师  杰青  长江特聘教授  973首席科学家

1999年获中科院上海脑研究所分子遗传学博士学位。1999-2007年在美国宾夕法尼亚大学妇女生殖健康研究中心做博士后及研究助理。 2007年5月被复旦大学引进聘为教授。现为复旦大学生殖发育研究院院长、生命科学学院、生物医学研究院兼职PI。曾获全国妇幼健康研究会首届自然科学一等奖、教育部自然科学一等奖、连续三次美国妇产科研究学会大会报告“主席奖”、全国五一劳动奖章、中国青年女科学家奖、谈家桢生命科学奖、药明康德生命化学杰出成就奖、上海市领军人才、上海市优秀学科带头人等荣誉。

Email: wanghy@fudan.edu.cn

代表性论著:

1. Li C†, Li HD†, Yao XY, Liu D, Wang YM, Huang XY, Yang ZZ, Tao WF, Zhao JY* and Wang HY*. Master microRNA-222 regulates cardiac microRNA maturation and triggers Tetralogy of Fallot. Signal Transduction and Targeted Therapy, 2022; 7:165 

2. Wang YL, Cao XT, Liu P, Zeng WJ, Peng R, Shi Q, Feng K, Zhang PZ, Sun HR, Wang CJ* and Wang HY*. KCTD7 mutations impair the trafficking of lysosomal enzymes through CLN5 accumulation to cause neuronal ceroid lipofuscinoses. Science Advances, 2022;eabm5578

3. Qin Y†, Du YS†, Chen LQ, Liu YY, Xu WJ, Liu Y, Li Y, Leng J, Wang YL, Zhang XY, Feng JF, Zhang F, Jin L, Qiu ZL, Gong XH* and Wang HY*. A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling. Mol Psychiatry , 2022

4. Zhao JY#, Qiao B#,DuanWY#, GongXH, Jiang SS, YeZZ, Wang J, Gu ZY, Shen HB, Shi KH, Sun SN, Huang GY*, Jin L*,WangHY*. Genetic variantsreducing MTR gene expression increase riskof congenital heart disease in a Chinese population. European Heart Journal , 2013

5. ZhaoJY#, Yang XY#,ShiKH#, SunSN, Hou J, Ye ZZ,Wang J, Duan WY, Qiao Bin, Chen YJ, Shen HB, Huang GY, Jin L,Wang HY*. A Functional Variantin the Cystathionine -SynthaseGene Promoter Significantly Reduces Congenital Heart DiseaseSusceptibility in Han Chinese Population. Cell Research, 2013;23:242-253.

6. Yang XY#, Zhou XY#,WangQQ#, Li H,Chen Y, Lei PP,Ma XH, Kong P, Shi Y, Jin L, Zhang T*, Wang HY*. Mutations inthe COPII Vesicle Component GeneSEC24B are Associated with HumanNeural Tube Defects. Hum Mut, 2013.

7. ZhaoJY, YangXY, Gong XH，GuZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Huang GY,Jin L,Qiao B*, and Wang HY* (2012).A functional variant in MTRR intron-1significantly increases risk ofcongenital heart disease in HanChinese population. Circulation, 2012;125:482-490.

8. ShiY#, Ding Y#,LeiYP#, YangXY, Xie GM, WenJ, Cai CQ, Li H, Chen Y, Zhang T, Wu BL, Jin L, Chen YG*, Wang HY*(). Identification of novelloss-of-function mutations of DACT1 inhuman neural tube defects. Human Mutation, 2012;33(10): 1450-1455.

9. Lei YP, Zhang T, Li H, Wu BL, JinL, WangHY*. VANGL2 Mutations Identified in Human Cranial Neural-Tube Defects. N Engl J of Med. 2010;362(23):2232-2235.

10. WangH,Parry S, Macones G, SammelMD,Kuivaniemi H, Tromp G, Halder I, ShriverMD, RomeroR, StraussJF (2006) AFunctionalSNP in thePromoter of the SERPINH1 Gene Encoding Hsp47 Increases Riskof PretermPremature Rupture of Membranes and Preterm Birth inAfrican-Americans. PNAS, 2006;103(36):13463-13467.