Chao Li#, Hongdou Li#, Xiaoying Yao, Dong Liu, Yongming Wang, Xinyi Huang, Zhongzhou Yang, Wufan Tao, Jianyuan Zhao* and Hongyan Wang*. Master microRNA-222 regulates cardiac microRNA maturation and triggers Tetralogy of Fallot. Signal Transduct Target Ther. 2022 May 30;7(1):165.

Yue Qin#, Yasong Du#, Liqiang Chen, Yanyan Liu, Wenjing Xu, Ying Liu, Ying Li, Jing Leng, Yalan Wang, Xiao-Yong Zhang, Jianfeng Feng, Feng Zhang, Li Jin, Zilong Qiu, Xiaohong Gong* and Hongyan Wang*. A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling. Mol Psychiatry. 2022;27(7):2985-2998.

Yalan Wang, Xiaotong Cao, Pei Liu, Weijia Zeng, Rui Peng, Qing Shi, Kai Feng, Pingzhao Zhang, Huiru Sun, Chenji Wang* and Hongyan Wang*. KCTD7 mutations impair the trafficking of lysosomal enzymes through CLN5 accumulation to cause neuronal ceroid lipofuscinoses. Science Advances. 2022, 8(31), eabm5578.

Ying Zhao#, Duoyuan Chen#, Jianping Tang, Yufang Zheng*, Ji Qi* and Hongyan Wang*. Parental folate deficiency induces birth defects in mice accompanied with increased de novo mutations. Cell Discov. 2022 Feb 22;8(1):18.

Rui Peng#, Binbin Li#, Shuxia Chen, Zhiwen Shi, Liwei Yu, Yunqian Gao, Xueyan Yang, Lei Lu* and Hongyan Wang*. Deleterious Rare Mutations of GLI1 Dysregulate Sonic Hedgehog Signaling in Human Congenital Heart Disease. Frontiers in Cardiovascular Medicine. 2022, 9:798033.

Yunqian Zhang, Rui Peng, Hongyan Wang. Identification and genetic analysis of rare variants in myosin family genes in 412 Han Chinese congenital heart disease patients. Molecular Genetics & Genomic Medicine. 2022,00:e2041

Yalan Wang, Yue Qin, Rui Peng and Hongyan Wang. Loss-of-function or gain-of-function variations in VINCULIN (VCL) are risk factors of human neural tube defects. Mol Genet Genomic Med. 2021 Feb;9(2):e1563.

Zhiwen Shi, Qingguo Zhao, Bin Lv, Xiao Han, Hongyan Wang*, Junjun Qiu* and Keqin Hua*. Identification of biomarkers complementary to homologous recombination deficiency for improving the clinical outcome of ovarian serous cystadenocarcinoma. Clin Transl Med. 2021 May;11(5):e399.

Lele Kuang, Yuchao Jiang, Shuxia Chen, Ke Su, Rui Peng, Xueyan Yang* and Hongyan Wang*. Rare variants in TULP3 abolish the suppressive effect on sonic hedgehog signaling and contribute to human neural tube defects. Genes Dis. 2021 Dec 8;9(5):1174-1177.

Yumeng Wang, Yu Wu, Yufang Zheng* and Hongyan Wang*. MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα. Cell Death Dis. 2021 Oct 25;12(11):999.

Zhiwen Shi, Jianfeng Shen, Junjun Qiu, Qingguo Zhao, Keqin Hua* and Hongyan Wang*. CXCL10 potentiates immune checkpoint blockade therapy in homologous recombination-deficient tumors. Theranostics. 2021 May 24;11(15):7175-7187.

Xinyu Mei^#, Dashi Qi^#, Ting Zhang^#, Ying Zhao^#, Li Jin, Junli Hou, Jianhua Wang, Yan Lin, Yu Xue, Pingping Zhu, Zexian Liu, Lei Huang, Ji Nie, Wen Si, Jingyi Ma, Jianhong Ye, Richard H. Finnell, Hexige Saiyin, Hongyan Wang*, Jianyuan Zhao*, Shimin Zhao* and Wei Xu*. Inhibiting MARSs reduces hyperhomocysteinemia-associated neural tube and congenital heart defects. EMBO Mol Med. 2020 Mar 6;12(3):e9469. 

Huili Li, Xiaolei Wang, Huizhi Zhao, Fang Wang, Yihua Bao, Jin Guo, Shaoyan Chang, Lihua Wu, Haiqin Cheng, Shuyuan Chen, Jizhen Zou, Xiaodai Cui, Lee Niswander, Richard H. Finnell, Hongyan Wang* and Ting Zhang*. Low folate concentration impacts mismatch repair deficiency in neural tube defects. Epigenomics. 2020 Jan;12(1):5-18.

Yifang Xie, Qiaozi Wang, Ning Gao, Fujian Wu, Feng Lan, Feng Zhang, Li Jin, Zheyong Huang, Junbo Ge*, Hongyan Wang* and Yongming Wang*. MircroRNA-10b Promotes Human Embryonic Stem Cell-Derived Cardiomyocyte Proliferation via Novel Target Gene LATS1. Mol Ther Nucleic Acids. 2020 Mar 6;19:437-445.

Hongdou Li, Bingjuan Cheng, Xuyun Hu, Chao Li, Jiasun Su, Shanshan Zhang, Ling Li, Mengting Li, Kai Yang, Sheng He, Shaoke Chen, Hongyan Wang*, Geli Liu* and Yiping Shen*. The first two Chinese Myhre syndrome patients with the recurrent SMAD4 pathogenic variants: Functional consequences and clinical. Clin Chim Acta, 2020 Jan;500:128-134.

Jianhong Ye, Youli Tong, Jiashun Lv, Rui Peng, Shuxia Chen, Lele Kuang, Ke Su, Yufang Zheng, Ting Zhang, Feng Zhang, Li Jin, Xueyan Yang* and Hongyan Wang*. Rare mutations in the autophagy‐regulating gene AMBRA1 contribute to human neural tube defects, Human Mutation, 2020, 41: 1383-1393.

Yumeng Wang, Yufang Zheng, Siyu Yang, Linna Zhang, Yanqin He, Xiaohong Gong, Dong Liu, Richard H. Finnell, Zilong Qiu, Yasong Du* and Hongyan Wang*. MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitors. Cell Death Differ, 2019 Oct; 26(10):1863-1879.

Zhiwen Shi, Shuxia Chen, Xiao Han, Rui Peng, Jing Luo, Luming Yang, Yufang Zheng* and Hongyan Wang*. The rare mutation in the endosome-associated recycling protein gene VPS50 is associated with human neural tube defects, Molecular Cytogenetics, 2019, 12: 8.

Linna Zhang^#, Yue Qin^#, Xiaohong Gong^#, Rui Peng, Chunquan Cai, Yufang Zheng, Yasong Du* and Hongyan Wang*. A promoter variant in ZNF804A decreasing its expression increases the risk of autism spectrum disorder in the Han Chinese population, Translational Psychiatry, 2019, 9: 31.

Yifang Xie, Anyun Ma, Boshi Wang, Rui Peng, Yingchun Jing, Richard Finnell, Bin Qiao, Yongming Wang, Hongyan Wang* and Yufang Zheng*. Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling, Clinical Science, 2019,133: 225-238.

Xiangyu Zhou, Mengjia Xu, Wei Zeng, Zhongzhong Chen, Guohui Lu, Yun Gong, Richard H. Finnell, Huasheng Xiao, Bin Qiao* and Hongyan Wang*. Combined effects of FH (E404D) and ACOX2 (R409H) cause metabolic defects in primary cardiac malignant tumor.  Cell Death Discov, 2018 Jul 23;4:18.

Chen Z#, Lei Y#, Zheng Y#, Aguiar-Pulido V, Ross M.E., Peng R, Jin L, Zhang T*, Finnell R.H.,*, Wang H*. Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Research. 2018；28 (10): 1039-1041.

Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X*, Zheng Y*, Miao Sun*. Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death Dis. 2018 May 3;9(5):520. doi: 10.1038/s41419-018-0563-4.

Gao X, Finnell R, Wang H, Zheng Y*. Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid. Birth Defects Res A 2018 May 6. doi: 10.1002/bdr2.1336. 

Kim J#, Lei Y#, Guo J, Kim S, Wlodarczyk B, Robert M. Cabrera RM, Lin Y, Nilsson T,  Zhang T, Ren A, Wang L, Yuan Z, Zheng Y, Wang H*, Finnell RH.* Formate Rescues Neural Tube Defects Caused by Mutations in Slc25a32. PNAS, 2018 May 1;115(18):4690-4695. doi: 10.1073/pnas.1800138115.

Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, Peng R, Finnell RH*, Zhang T*, Wang H*. Genetic analysis of Wnt/PCP genes in neural tube defects. BMC Med Genomics. 2018 Apr 4; 11(1): 38. doi: 10.1186/s12920-018-0355-9.

Shi Z, Yang X, Li B, Chen S, Yang L, Chen L, Zhang T, Wang H, Zheng Y*. Novel mutation of LRP6 identified in Chinese Han population links canonical WNT signaling to neural tube defects. Birth Defects Res A 2018 Jan 15;110(1):63-71. doi: 10.1002/bdr2.1122. Epub 2017 Sep 29.

Wang F^#, Liu D^#, Zhang RR, Yu LW, Zhao JY, Yang XY, Jiang SS, Ma D, Qiao B, Zhang F, Jin L, Gui YH*, Wang HY*. A TBX5 3'UTR variant increases the risk of congenital heart disease in the Han Chinese population. Cell Discov. 2017 Jul 25; 3:17026.

Li P^#, Huang L^#, Zheng Y, Pan X, Peng R, Jiang Y, Finnell RH, Li H, Qiao B, Wang HY*. A missense mutation in TCN2 is associated with decreased risk for congenital heart defects and may increase cellular uptake of vitamin B12 via Megalin. Oncotarget. 2017 Jul 19; 8(33):55216-55229.(IF 5.168)

Zhou X, Zeng W, Peng R, Wang H*. A hypoxia-inducible factor 1α null splice variant lacking exon 10. Cell Death Dis. 2017 Jun 15; 8(6):e2873.(IF 5.965)

Zhou X, Wang H*. ACOX2 deficiency in primary malignant cardiac tumors. Proc Natl Acad Sci U S A. 2017 May 2; 114(18):E3590-E3591.(IF 9.661)

Wang D^#, Wang F^#, Shi KH^#, Tao H, Li Y, Zhao R, Lu H, Duan WY, Qiao, B, Zhao SM*, Wang HY*, Zhao JY*. Lower Circulating Folate Induced by a Fidgetin Intronic Variant is Associated with Reduced Congenital Heart Disease Susceptibility. Circulation 2017 May 2; 135(18):1733-1748.(IF 19.309)

Qiao X, Liu Y, Li P, Chen Z, Li H, Yang X, Finnell RH, Yang Z, Zhang T, Qiao B, Zheng Y*, Wang H*.. Genetic analysis of rare coding mutations of CELSR1–3 in congenital heart and neural tube defects in Chinese people. Clin Sci 2016, 130: 2329–2340 (IF 4.936)

Jiang YC#, Kuang LL#, Sun SN, Duan WY, Qiao B, Wang HY*. Association of genetic polymorphisms of de novo nucleotide biosynthesis with increased CHD susceptibility in the northern Chinese population. Clin Genet. 2016, 91(5):748-755.(IF 3.326)

Yu LW^#, Wang F^#, Yang XY, Sun SN, Zheng YF, Li BB, Gui YH*, Wang HY*. Mild decrease in TBX20 promoter activity is a potentially protective factor against congenital heart defects in the Han Chinese population. Sci Rep. 2016. 6: 23662 (IF 4.259)

An Y, Duan WY, Huang GY, Chen XY, Li L, Nie CX, Hou J, Gui YH, Wu YM, Zhang F, Shen YP, Wu BL* and Wang HY*. Genome-wide copy number variant analysis for congenital ventricular septal defects in Chinese Han population. BMC Medical Genomics. 2016. 9:2 (IF 2.848)

Li PQ# , Li HJ, Zheng YF , Qiao B , Duan WY, Huang LJ , Liu WQ , Wang HY*. Variants in the Regulatory Region of WNT5A Reduced Risk of Cardiac Conotruncal Malformations in the Chinese Population. Sci Rep. 2015. 5:13120.(IF 5.228)

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Zhang X, Du RQ,Li SL, Zhang F, Jin L and Wang HY*(2014). Evaluation ofcopy number variation detection for a SNP arrayplatform.BMC Bioinformatics DOI:10.1186 /1471-2105-15-50

Zhao JY#, Qiao B#,DuanWY#, GongXH, Jiang SS, YeZZ, Wang J, Gu ZY, Shen HB, Shi KH, Sun SN, Huang GY*, Jin L*,WangHY* (2013). Genetic variantsreducing MTR gene expression increase riskof congenital heart disease in a Chinese population. European Heart Journal (IF14.1)(DOI: 10.1093 /eurheartj/eht221)

ZhaoJY#, Yang XY#,ShiKH#, SunSN, Hou J, Ye ZZ,Wang J, Duan WY, Qiao Bin, Chen YJ, Shen HB, Huang GY, Jin L,Wang HY(2013). A Functional Variantin the Cystathionine -SynthaseGene Promoter Significantly Reduces Congenital Heart DiseaseSusceptibility in Han Chinese Population. Cell Research ( 23:242-253,IF10.53 )

Yang XY#, Zhou XY#,WangQQ#, Li H,Chen Y, Lei PP,Ma XH, Kong P, Shi Y, Jin L, Zhang T*, Wang HY*(2013). Mutations inthe COPII Vesicle Component GeneSEC24B are Associated with HumanNeural Tube Defects. Hum Mut(DOI:10.1002/humu.22338) (5-year IF=5.76)

WangEL#, Jin WF#,DuanWY#, QiaoB, Sun SN, HuangGY, Shi KH, Jin L*, Wang HY*(2013). Association of TwoVariants inSMAD7 with the Risk of Congenital Heart Disease in the HanChinesePopulation. PLoS ONE 8(9): e72423 ( 5-year IF=4.24)

Wang EL#,Sun SN#, Qiao B, Duan WY, HuangGY, An Y, Xu SH, Zheng YF, Su ZX, GuX,Jin L*, Wang HY* (2013). Identification of FunctionalMutationsin GATA4 in Patients with Congenital Heart Disease.PLoS ONE 8(4):e62138 (5-year IF=4.24)

ZhaoJY, YangXY, Gong XH，GuZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Huang GY,Jin L,Qiao B*, and Wang HY* (2012).A functional variant in MTRR intron-1significantly increases risk ofcongenital heart disease in HanChinese population. Circulation(125:482-490, IF=15.2)

ShiY#, Ding Y#,LeiYP#, YangXY, Xie GM, WenJ, Cai CQ, Li H, Chen Y, Zhang T, Wu BL, Jin L, Chen YG*, Wang HY*(2012). Identification of novelloss-of-function mutations of DACT1 inhuman neural tube defects. Human Mutation( 33 (10): 1450-1455,5-yearIF=5.76)

ZhaoJY#, Sun JW#,Gu ZY#，WangJ, Wang EL, Yang XY, QiaoB, Duan WY, Huang GY, and WangHY*(2012).Genetic Polymorphisms of the TYMS Gene are not associatedwithCongenital Cardiac Septal Defects in a Han Chinese Population.PLoS ONE 7(2):e31644 ( 5-year IF=4.24)

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