个人简介

       2015年于南京大学获得遗传学博士学位。2016年至今于复旦大学-上海中科院生化细胞所进行遗传学以及发育生物学研究。

研究方向

       利用单倍体干细胞技术，建立人类疾病突变小鼠模型。

代表性论文

1. Rui Peng#, Binbin Li#, Shuxia Chen, Zhiwen Shi, Liwei Yu, Yunqian Gao, Xueyan Yang, Lei Lu* and Hongyan Wang*. Deleterious Rare Mutations of GLI1 Dysregulate Sonic Hedgehog Signaling in Human Congenital Heart Disease. Frontiers in Cardiovascular Medicine, 2022, 9:798033.
2. 徐畅，彭瑞，王红艳，卢磊，DNMT1错义突变与神经管畸形易感性的相关性研究，基因组学与应用生物学，2021，40(2): 841-848.

3. 李铃，彭瑞，王红艳，卢磊，SMAD4错义突变与先天性心脏病易感性的相关性研究，基因组学与应用生物学，2021，40 (1): 395-399.

4. Lu Lei*, Gao Yan*, Zhang Zan, Cao Qing, Zhang XN, Zou JH, and Cao Ying. (2015) Kdm2a/b Lysine Demethylases Regulate Canonical Wnt Signaling by Modulating the Stability of Nuclear β-Catenin. Developmental Cell. V33-6, 660-674
5. Cao Qing*, Zhang XN*, Lu Lei, Yang LN, Gao JM, Gao Yan, Ma HH, and Cao Ying. (2012) Klf4 is required for germ-layer differentiation and body axis patterning during Xenopus embryogenesis. Development. 139, 3950-3961
6. Zhang XN, Gao Yan, Lu Lei, Zhang Zan, Gan SC, Xu LY, Lei AH and Cao Ying. (2015) JmjC Domain-containing Protein 6 (Jmjd6) Derepresses the Transcriptional Repressor Transcription Factor7-like 1 (Tcf7l1) and Is Required for Body Axis Patterning during Xenopus Embryogenesis. Journal of Biological Chemistry. 290, 20273-20283
7. Gao Yan, Cao Qing, Lu Lei, Zhang XN, Zhang Zan, Dong XH ,Jia WS and Cao Ying. (2015) Kruppel-like factor family genes are expressed during Xenopus embryogenesis and involved in germ layer formation and body axis patterning. Developmental Dynamics.
8. Gao YQ, Chen Xin, Wang Pei, Lu Lei, Zhao Wei, Chen Chen, Chen CP, Tao Tao, Sun Jie, Zheng YY, Du Jie, Li CJ, Gan ZJ, Gao Xiang, Chen HQ and Zhu MS. (2015) Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. Proceedings of the National Academy of Science.